Efficacy of dupilumab for the treatment of severe skin disease in cytotoxic T lymphocyte antigen-4 insufficiency: A role of type 2 inflammation?

L. Karla Arruda, Daniel L. Cordeiro,Sarah S. Langer,Marcel Koenigham-Santos,Rodrigo T. Calado,Marina M. Dias,Leonardo R. Anhesini,João Bosco Oliveira,Bodo Grimbacher,Mariana P.L. Ferriani

Journal of Allergy and Clinical Immunology: Global（2023）

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摘要

We report on the successful treatment of a severe, recalcitrant dermatitis caused by CTLA-4 insufficiency with dupilumab, raising the possibility of a role of type 2 immunity in clinical conditions associated with CTLA-4 insufficiency.

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Dermatitis,cytotoxic T-lymphocyte antigen-4 insufficiency,dupilumab,abatacept,inborn errors of immunity

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