Interrelated but Not Time-Aligned Response in Myogenic Regulatory Factors Demethylation and mRNA Expression after Divergent Exercise Bouts.

Guilherme Defante Telles,Cleiton Augusto Libardi,Miguel Soares Conceição,Felipe Cassaro Vechin,Manoel Emílio Lixandrão,Flavia Regina Rotea Mangone,Ana Carolina Pavanelli,Maria Aparecida Nagai,Donny Michael Camera,John A Hawley,Carlos Ugrinowitsch

Medicine and science in sports and exercise（2023）

引用 6|浏览16

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摘要

We observed an interrelated but not time-aligned response between the exercise-induced changes in myogenic regulatory factors demethylation and mRNA expression after divergent exercise modes. Despite divergent contractile stimuli, changes in DNA methylation and mRNA expression in skeletal muscle were largely confined to the late (4-8 h) recovery period and similar between the different exercise challenges.

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关键词

MYOD1,MYF5,MYF6,EPIGENETICS,ANABOLIC

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