Preclinical and Clinical Trial Results Using Talazoparib and Low-Dose Chemotherapy.

Zev A Wainberg,Arun S Singh,Gottfried E Konecny,Kelly E McCann,J Randolph Hecht,Jonathan Goldman,Bartosz Chmielowski,Richard S Finn,Neil O'Brien,Erika Von Euw, Megan M Price,Diego Martinez, Lisa Yonemoto,Meghan Brennan,John A Glaspy,Dennis J Slamon

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

These results show that talazoparib with low-dose temozolomide or irinotecan is reasonably well tolerated and demonstrates clinical activity in a wide range of cancers. Randomized trials of talazoparib with or without low-dose chemotherapy are ongoing in small cell lung cancer and ovarian cancer.

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talazoparib,chemotherapy,preclinical trial results,preclinical trial,low-dose low-dose

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