Role of T CD4 + cells, macrophages, C-low threshold mechanoreceptors and spinal Ca v 3.2 channels in inflammation and related pain-like symptoms in murine inflammatory models.

Elodie Picard,Nicolas Kerckhove,Amaury François,Ludivine Boudieu,Elisabeth Billard,Frédéric Antonio Carvalho,Gemma Bogard,Philippe Gosset,Justine Bourdier,Youssef Aissouni,Emmanuel Bourinet,Alain Eschalier,Laurence Daulhac,Christophe Mallet

British journal of pharmacology（2023）

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摘要

Ca 3.2 channels play crucial roles in inflammation and related pain, implying that targeting of Ca 3.2 channels with pharmacological agents could be an attractive and readily evaluable strategy in clinical trials, to relieve chronic inflammatory pain in patients.

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关键词

T-type calcium channels,inflammation,inflammatory pain,mechanical hypersensitivity,pharmacology

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