Inhibition of Phosphoinositide 3-Kinase Gamma Protects Endothelial Cells via the Akt Signaling Pathway in Sepsis-Induced Acute Kidney Injury.

Han Li,Jun-Xian Xu,Tiao-Chun Cheng,Li-Jun Tian,Jin-Feng Lin,Xi Luo,Zhao-Lian Bian,Xu-Dong Han

Kidney & blood pressure research（2022）

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摘要

In this study, endothelial cell dysfunction plays an important role in sepsis-induced AKI, and the inhibition of PI3Kγ alleviates endothelial cell injury in sepsis-induced AKI through the PI3Kγ/Akt pathway, providing novel targets for treating sepsis and related kidney injury.

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关键词

Acute kidney injury,Endothelial cell,Phosphoinositide 3-kinase gamma,Sepsis

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