Volanesorsen, an antisense oligonucleotide to apolipoprotein C-III, increases lipoprotein lipase activity and lowers triglycerides in partial lipodystrophy

Marissa Lightbourne,Megan Startzell,Kimberley D. Bruce,Brianna Brite,Ranganath Muniyappa,Monica Skarulis,Robert Shamburek,Ahmed M. Gharib,Ronald Ouwerkerk,Mary Walter,Robert H. Eckel,Rebecca J. Brown

Journal of Clinical Lipidology（2022）

引用 3|浏览17

暂无评分

摘要

•Volanesorsen suppressed apolipoprotein C-III (apo C-III) in partial lipodystrophy.•Lowering of apo C-III increased lipoprotein lipase (LPL) activity.•Volanesorsen lowered serum triglycerides, likely by activating LPL.•Peripheral, hepatic, and adipose insulin sensitivity increased after volanesorsen.

查看译文

关键词

Partial lipodystrophy,Apolipoprotein C-III,Triglycerides,Lipoprotein lipase,Insulin resistance,Hepatic steatosis

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要