Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes

Sanjiv Kaul,Carmen Methner,Zhiping Cao,Anusha Mishra

JACC: Basic to Translational Science（2023）

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摘要

•Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow.•Reversing pericyte contraction pharmacologically reduces no reflow and infarct size.•These findings open up an entire new venue of research aimed at pericyte function.

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关键词

acute myocardial infarction,blood flow,necrosis,no reflow,pericytes

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