Robust polyamide-PTFE hollow fibre membranes for harsh organic solvent nanofiltration

•Microfiltration PTFE hollow fibres were transformed into durable, high value OSN membranes.•A PEI/PIP based polyamide thin film was successfully synthesized on PTFE hollow fibre substrates.•A two-time interfacial polymerization was conducted to obtain a defect-free polyamide layer.•The resultant membranes could withstand strong aprotic solvents like DMF and DMSO.•The membranes had high solute rejections, of up to 95 % methyl orange (327 Da) rejection in DMF.