In vivo induction of regulatory T cells by anti-CD45RB antibody causes transferable tolerance to discordant human xenogenic islets.

Yanling Zhang,Maozhu Yang,Guiqing Jia,Shaoping Deng,Ji Lei,James Markmann,Gaoping Zhao

Xenotransplantation（2022）

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摘要

The results of the experiment suggest that anti-CD45RB induced tolerance to human islet xenografts is mediated by the proliferation of Tregs. These tolerogenic Tregs can be transferred to other mice and induce nonspecific immune tolerance.

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关键词

Tregs,anti-CD45RB,immune tolerance,nonspecific immune tolerance,xenotransplantation

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