Negative porosity issue in the Heckel analysis: A possible solution

Devang Patel,Vivek D Patel,Robert Sedlock,Rahul V Haware

International Journal of Pharmaceutics（2022）

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摘要

•Pycnometric tablet density can resolve Heckel negative porosity issue.•New approach allows efficient use of full Heckel plot without negative porosity.•New approach can overcome the limitations of modified Heckel equation approach.

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关键词

Heckel analysis,Modified Heckel equation,Negative porosity,Pycnometric tablet density,Pycnometric powder density,Relative density,True density

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