Poster: CT-009 Prognostic Role of Lymphocyte to Monocyte Ratio in PTS Treated With CAR-T for Aggressive Lymphoma

Radhika Bansal,Henan Zhang,Kodi E Martinez,Matthew Hathcock,Zuoyi Shao,Gabrielle Gonzalez McCoy,Anatilde Gonzalez-Guerrico,Nora Bennani,Jonas Paludo,Yucai Wang,Patrick B. Johnston,Stephen M. Ansell,Saad Kenderian,Luis Porrata,Jose C. Villasboas,Yi Lin

Clinical Lymphoma Myeloma and Leukemia（2022）

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摘要

ALC/AMC is a clinically accessible test that is strongly associated with CAR-T response and survival. Immune characterization revealed that the biological effect is not just associated with cell numbers. Phenotypes such as monocytes with inflammatory capacity and T cell subsets may further distinguish between primary refractory disease, early relapse, and durable response. These data could inform future therapeutic strategies to improve clinical outcomes with CAR-T.

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关键词

CT,CAR-T,Lymphoma,biomarker

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