Poster: AML-147 C-MYC Targeting by Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Exerts Profound Cell Kill In Vitro and In Vivo in Acute Myeloid Leukemia and Lymphomas

Yuki Nishida,Darah A Scruggs,Edward Ayoub,Tallie Patsilevas,Vivian R Ruvolo,Po Yee Mak,Bing Z Carter,Steffen Boettcher,Abhishek Maiti,Qianxiang Zhou,Zhaohui Yang,Honghua Yan,Liandong Ma,Michael Andreeff

Clinical Lymphoma Myeloma and Leukemia（2022）

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摘要

First results with the novel dual c-Myc/GSPT1 degrader GT19715 demonstrate promising preclinical anti-lymphoma and -leukemia efficacy, providing rationale for its clinical development.

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关键词

AML,Myc-driven lymphoma/leukemia,Myc degrader,CELMoDs,GSPT1

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