AML-259 Pharmacokinetics and Bioequivalence of Two Formulations of GFH009 Maleate Injection in Sprague Dawley Rats

Fusheng Zhou,Jinzhu Zhao,Dragan Cicic,Jiong Lan,Qiang Lu

Clinical Lymphoma Myeloma and Leukemia（2022）

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摘要

The PK profiles of GFH009 were comparable following single IV administration of two formulations of GFH009 maleate injection in SD rats, which supported application of the pH 6.0 formulation in Phase I trials in patients with relapsed/refractory hematologic conditions, including AML and lymphoma.

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AML,GFH009,CDK9,pharmacokinetics,half-life,SD rats

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