15.4.5 Quinolinones and Related Systems (Update 2022)

V. L. M. Silva,D. C. G. A. Pinto,C. M. M. dos Santos,D. H. A. Rocha

Knowledge Updates 2022/3（2022）

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摘要

AbstractQuinolinones, of which the quinolin-4(1H)-one ring system can be highlighted, represent an exciting class of nitrogen heterocycles. The quinolinone motif can be found in many natural compounds and approved drugs for several diseases. This chapter is a comprehensive survey of the methods for the synthesis of quinolin-2(1H)-ones, quinolin-4(1H)-ones, and their thio- and amino derivatives, and is an update to the previous Science of Synthesis chapter (Section 15.4), covering the period between 2003 and 2020.

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关键词

amides, amines, anilines, annulations, carbon-carbon bonds, carbonnitrogen bonds, carbonyl compounds, enaminones, heterocycles, lactamization, nitrogen heterocycles, palladium catalysts, quinolines, quinolin-2(1H)-ones, quinolin-4(1H)-ones, quinolinamines, ring-closing reactions, ring expansion, tandem reactions

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