Novel Ru(II)-bipyridine/phenanthroline-lapachol complexes as potential anti-cancer agents

Rone Aparecido De Grandis,Analu Rocha Costa,Carlos André Ferreira Moraes,Natália Zaneti Sampaio, Igor Henrique Cerqueira, Wellington Garcia Marques,Adriana Pereira Mundin Guedes,João Honorato de Araujo-Neto,Fernando Rogério Pavan,Felipe Cerqueira Demidoff,Chaquip Daher Netto,Alzir Azevedo Batista,Flávia Aparecida Resende

Journal of Inorganic Biochemistry（2022）

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摘要

For the first time, we herein report on the syntheses of two new Ru(II)/bipyridine/phenanthroline complexes containing lapachol as ligand: complex (1), [Ru (bipy)2(Lap)]PF6 and complex (2), [Ru(Lap)(phen)2]PF6, where bipy = 2,2′-bipyridine and ph en = 1,10-phenanthroline; Lap = lapachol (2-hydroxy-3-(3-methylbut-2-en-1-

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关键词

Ruthenium complexes,Cytotoxicity,Reactive oxygen species,Genotoxicity,Lapachol

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