Medication overuse headache associated with decreased dopamine transporter availability in the medial but not in the lateral orbitofrontal cortex: a 11 CFT PET/MR study.

Huanxian Liu,Jiajin Liu,Shuping Sun,Wei Dai,Binbin Nie,Baixuan Xu,Zhao Dong,Shengyuan Yu

The International journal of neuroscience（2022）

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摘要

MOH is characterised by decreased DAT availability in the medial OFC, which might reflect compensatory downregulation due to low dopamine signalling within the mesocorticolimbic dopamine system and provide a new perspective to understand the pathogenesis of MOH.

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关键词

PET/MR,dopamine transporter,medication overuse headache,orbitofrontal cortex

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