Celastrol inhibits rheumatoid arthritis by inducing autophagy via inhibition of the PI3K/AKT/mTOR signaling pathway

Junjie Yang,Jiayu Liu,Jing Li,Ming Jing,Leiming Zhang,Mengmeng Sun,Qiaoyun Wang,Hongliu Sun,Guige Hou,Chunhua Wang,Wenyu Xin

International Immunopharmacology（2022）

引用 14|浏览7

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摘要

•Celastrol improved arthritis symptoms of CIA mice.•Celastrol inhibited TNF-α-induced FLS proliferation.•Celastrol increased expressions of autophagy-related proteins in vitro and vivo.•Celastrol inhibited the PI3K/AKT/ mTOR signaling pathway in vitro and vivo.•Celastrol have antarthritic effect by regulating autophagy and PI3K/AKT/mTOR axis.

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关键词

Celastrol,Rheumatoid Arthritis,Fibroblast-like Synoviocytes,Autophagy,PI3K/AKT/mTOR Pathway

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