Mapping the landscape of genetic dependencies in chordoma

Tanaz Sharifnia,Mathias J. Wawer,Amy Goodale,Yenarae Lee,Mariya Kazachkova,Joshua M. Dempster,Sandrine Muller,Joan Levy,Daniel M. Freed,Josh Sommer,Jérémie Kalfon,Francisca Vazquez,William C. Hahn,David E. Root,Paul A. Clemons,Stuart L. Schreiber

Nature Communications（2023）

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摘要

Cancer cells possess unique molecular features that can confer an increased dependence on specific genes. Here, the authors use CRISPR-Cas9 screens to identify selectively essential genes and therapeutic targets in chordoma.

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关键词

Bone cancer,Cancer genetics,Functional genomics,Science,Humanities and Social Sciences,multidisciplinary

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