Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications.

Adria-Jaume Roura,Paulina Szadkowska,Katarzyna Poleszak,Michal J Dabrowski,Aleksandra Ellert-Miklaszewska,Kamil Wojnicki,Iwona A Ciechomska,Karolina Stepniak,Bozena Kaminska,Bartosz Wojtas

Clinical epigenetics（2023）

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摘要

GBM-specific TFs-gene networks identified in GBMs differ from regulatory pathways attributed to benign brain tumors and imply a decisive role of c-Jun in controlling genes that drive glioma growth and invasion as well as a modulatory role of DNA methylation.

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关键词

Chromatin accessibility,DNA binding,DNA methylation,Gene expression,Glioblastoma,Transcription factors,Transcriptional deregulation

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