African swine fever virus MGF505-7R protein interacted with IRF7and TBK1 to inhibit type I interferon production

Kaidian Yang,Ying Xue,Tianming Niu,Xinyang Li,Mingyang Cheng,Meiying Bao,Boshi Zou,Chunwei Shi,Jianzhong Wang,Wentao Yang,Nan Wang,Yanlong Jiang,Guilian Yang,Yan Zeng, Xin Cao,Chunfeng Wang

Virus Research（2022）

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摘要

•ASFV MGF505-7R could inhibit cGAS-STING-mediated activation of IFN-β and ISRE promoters.•ASFV MGF505-7R specifically associated with TBK1, IRF7.•ASFV MGF505-7R interacted with IRF7, TBK1, degrading IRF7 expression by autophagy, cysteine, proteasome pathways and TBK1 expression by proteasome.

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关键词

MGF505-7R,TBK1,IRF7,Interferon,African swine fever virus

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