Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts Xiaojing Zhao , Wenjing Yang , Tianming Yu , Yu Yu , Xiufang Cui , Zheng Zhou , Hui Yang , Yanbo Yu , Anthony J Bilotta , Suxia Yao , Jimin Xu , Jia Zhou , Gregory S Yochum , Walter A Koltun , Austin Portolese , Defu Zeng , Jingwu Xie , Iryna V Pinchuk , Hongjie Zhang , Yingzi Cong Gastroenterology（2023）
摘要
Th17 cells induce more severe intestinal fibrosis through the production of Areg, which promotes human intestinal myofibroblast proliferation and migration. 更多 查看译文
关键词
Effector CD4+T Cells, Inflammatory Bowel Diseases, Intestinal Inflammation, Intestinal Myofibroblasts
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