A General Chemical Principle for Creating Closure-Stabilizing Integrin Inhibitors

Fu-Yang- Lin, Jing Lin,Yonghua Xie, Jiangha Zhu,Thi Thu Huong Nguyen,Yonghui Zhang,Jieqing Zhu,Timothy A. Springer

CELL（2022）

Cited 28|Views32

Key words

integrins,drug discovery,conformational change,thrombosis,autoimmune disease,membrane receptors,integrin inhibitors,conformations,agonism,αIIbβ3,α4β1,hydrogen bonds,conformation specificity

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