Thrombospondin 1 and Nuclear Factor Kappa B Signaling Pathways in Non-alcoholic Fatty Liver Disease.

Iskender Ekinci,Seyma Dumur,Hafize Uzun,Gulden Anataca, Isa Yalcinkaya,Mitat Buyukkaba,Ahmet Cinar,Hanise Ozkan,Irem Kirac Utku,Murat Akarsu,Omur Tabak

Journal of gastrointestinal and liver diseases : JGLD（2022）

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摘要

Our results suggest a close relationship between increased NF-κB and reduced TSP-1 in NAFLD. TSP-1 and NF-κB signaling pathways might have a role in the inflammatory and fibrogenic processes. Furthermore, they may be used as a noninvasive marker and could assist as a therapeutic target for NAFLD.

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Non-alcoholic fatty liver disease,thrombospondin-1,nuclear factor kappa B,inflammation,fibrogenesis

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