Bread crust extract protects rats’ vascular grafts from in vitro ischemia/reperfusion injury

Sevil Korkmaz-Icoz, Marcel Schwar,Sivakkanan Loganathan,Kristin Wachter,Adrian- Iustin Georgevici,Patricia Kraft,Tobias Mayer,Andreas Simm,Matthias Karck,Gabor Szabo

Journal of Functional Foods（2022）

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摘要

•Ischemia/reperfusion (IR) injury affects vascular grafts during bypass surgery.•Better organ preservation solutions against IR injury are needed.•Saline supplemented bread crust extract protects vascular grafts from IR injury.•Protection by reducing nitro-oxidative stress-induced cell death.•Protection by upregulation of the anti-oxidant gene Gclc.

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关键词

Ischemia/reperfusion,Endothelial dysfunction,Bread crust extract,Vascular function

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