Fate of HDV-specific CD8+T cells during bulevirtide monotherapy in patients with chronic hepatitis delta

Valerie Oberhardt,Elisabetta Degasperi,Marta Borghi,Kathrin Heim,Roberta Soffredini,Alessandro Loglio,Ozlem Sogukpinar,Frances Winkler,Bertram Bengsch,Maike Hofmann,Robert Thimme,Pietro Lampertico,Christoph Neumann-Haefelin

JOURNAL OF HEPATOLOGY（2022）

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摘要

Background and Aims Bulevirtide reduces HDV viremia in chronic HDV infection, however, long-term treatment is required to prevent relapse. Sustained treatment response may be fostered by therapy-induced restoration of HDV-specific CD8+T cells that are exhausted during chronic HDV infection. We thus studied the effect of bulevirtide monotherapy on HDV-specific CD8+T cell repertoire, phenotype, and functionality.

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关键词

bulevirtide monotherapy,chronic hepatitis,hdv-specific

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