Terbium-doped zinc oxide constructed dual-light-responsive nitric oxide-releasing platform for bacterial keratitis treatment
NANO RESEARCH(2022)
摘要
Bacterial keratitis (BK) is a principal factor contributing to corneal ulcers and ocular complications, and has become a significant killer of global vision health. Traditional antibiotic therapy has unsatisfactory therapeutic effect due to short residence time and low utilization rate of drug, and the long-term abuse of antibiotics can easily incur the prevalence of drug-resistant bacteria. Furthermore, antibiotics are not effective in addressing the excessive inflammatory response caused by infection. Here, we developed a terbium-doped zinc oxide constructed dual-light-responsive nitric oxide (NO)-releasing nanoparticle (ZT@P@B) and modified it on the surface of contact lenses (CL-ZT@P@B) to boost its bioavailability. In vitro and in vivo experimental results verified that ZT@P@B could simultaneously respond to green light (GL) and 808 nm near-infrared (NIR) without obvious damage to the eyes, releasing reactive oxygen species (ROS) and NO, which could effectively kill bacteria (including drug-resistant strains) and reduce inflammatory response. The platform provides a promising strategy for the prevention and treatment of BK.
更多查看译文
关键词
zinc oxide, nitric oxide, dual-light-responsive, bacterial keratitis, contact lenses
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要