Anti-inflammatory effects of two new stilbene-phenylpropanoid derivatives from Chamaecrista pumila

Two new stilbeno-phenylpropanoid compounds, given the trivial names chamaecristanols A and B (1 and 2), were isolated from the ethyl acetate-soluble partitions of separate methanol extracts of the aerial parts of Chamaecrista pumila (Lam.) K. Larsen. The structures of these compounds were determined on the basis of interpretation of their spectroscopic data and comparison with reported literature data. Their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells were evaluated. Results showed that compounds 1 and 2 significantly inhibited NO production with IC50 values of 41.69 ± 1.34 and 32.14 ± 0.15 µM, respectively.