Preventive and Therapeutic Effect of Lanthanide Coordination Polymers on Severe Burn Infection by Inhibiting Staphylococcus epidermidis Infection

In this work, two mixed-ligand lanthanide coordination polymers (CPs), that is, [La-2(MPIP)(2)(1,3-bdc)(2)(NO3)(2)](n) middot 3nH(2)O (1) and [La-2(MPIP)(1,3-bdc)(3)](n) (2), were successfully formed under solvothermal or hydrothermal conditions with the reactions between 2-(3-methylphenyl)imidazo(4,5-f)(1,10)-phenanthroline (MPIP), a N-donor ligand, and La(NO3)3middot 6H(2)O in the existence of benzene-1,3-dicarboxylic acid (1,3-H(2)bdc), a carboxylic acid ligand. Their application values on severe burn infection were examined, and the associated mechanism was analyzed. First, the Staphylococcus epidermidis bacterial number was counted after compound treatment. Second, ELISA was performed to test the inflammatory cytokines released into the skin tissue.