AI-700 pharmacokinetics, tissue distribution and exhaled elimination kinetics in rats

The purpose of these studies was to determine the pharmacokinetics, tissue distribution, and exhaled elimination kinetics in rats for intravenously administered AI-700, which consists of porous microspheres containing decafluorobutane (DFB), for use as an ultrasound contrast agent. [Pd]-AI-700 was administered intravenously to rats (10mgmicrospheres/kg). Blood and tissue samples collected at specified times were analyzed for palladium by inductively coupled plasma-mass spectrometry (ICP-MS). AI-700 was also administered intravenously to rats (40mgmicrospheres/kg) and expired air was collected over time. Expired air samples were analyzed for DFB by validated adsorbent trapping–thermal desorption–gas chromatography–mass spectrometry methodology.