Breast Cancer Disparities Related to Young Age at Diagnosis

Purpose of Review Despite being uncommon, breast cancer at a young age correlates with worse outcomes. Several aspects of a breast cancer diagnosis may affect young and older patients differently, including biology, genetic predisposition, fertility concerns, and psychosocial outcomes. Understanding these differences is critical to providing tailored, high-quality care to young patients. Recent Findings Young women with breast cancer are less likely to have early stage at presentation and more likely to have tumors with aggressive characteristics. Genetic mutations predisposing to breast cancer are more common. Due to their life stage, young women face concerns regarding fertility and pregnancy and are at higher risk for psychosocial distress. Summary Recent clinical trials in the adjuvant setting have provided insight on the optimal treatment for young patients. Multiple other studies have outlined the psychosocial impact of breast cancer in young patients, helping to understand their unique challenges. However, there is still need for further research, including around interventions, to address clinical and social concerns specific to young patients.