Experimental tooth loss affects spatial learning function and blood‐brain barrier of mice

Hiroshi Oue, Rie Hatakeyama,Eri Ishida,Miyuki Yokoi,Kazuhiro Tsuga

Oral Diseases（2022）

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摘要

Experimental tooth loss reduced the level of claudin-5 and caused astrogliosis in the brains of mice, which was accompanied by deterioration of learning functions. This study may provide a new insight about the association between tooth loss and cognitive dysfunction.

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关键词

experimental tooth loss,blood–brain barrier,spatial learning function,mice

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