In situ electrodeposition of bismuth oxide nanowires @MWNT on the carbon fiber microelectrode for the sensitively electrochemical detection of folic acid

A microminiaturized electrochemical device, BiO@CNW/CFE was fabricated based on the in situ co-electrodeposition of bismuth oxide nanowires (BiNWs) and multi-walled carbon nanotubes (MWNTs) on the surface of carbon fiber electrode (CFE). The nanostructure of BiNWs could bind MWNTs on the surface of CFE during the precipitation of bismuth at the potential of −1.1 V. The vimineous nanostructure of BiO@CNW improved the surface area and electrochemical activity of the microelectrode. With the low background noise, folic acid (FA) can be detected sensitively by BiO@CNW/CFE based on the electrochemical reduction via the method of square wave voltammetry. The linear range of FA in sodium acetate-acetic acid buffer was achieved in the range of 5.00 nM–200 nM, the detection limit was estimated to be 0.63 nM. The recoveries of FA in human serum and artificial cerebral spinal fluid were between 99% and 103%, which indicates BiO@CNW/CFE was a reliable sensor for the detection of FA in biological samples.