New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood

Almudena Ortega-Gomez,Sergio Lopez,Lourdes M Varela,Sara Jaramillo,Francisco J G Muriana,Rocio Abia

Food Chemistry: Molecular Sciences（2022）

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摘要

•SFAs but not MUFAs boosted neutrophils both in bone marrow and blood.•SFAs were strong inducers of bone marrow neutrophil apoptosis and inflammation.•CXCL2-CXCR2 axis engaged in fatty-acid-mediated navigation of neutrophils.•Fatty-acid-dependent neutrophilia occurred in a postprandial model.

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关键词

Olive oil,Butter,Dietary fatty acids,High-fat diets,Neutrophil mobilisation,Bone marrow inflammation

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