The Etv1/Er81 transcription factor coordinates myelination-related genes to regulate Schwann cell differentiation and myelination.

Parizat Askar,Jinghui Xu,Junxia Hu,Jianghong Shangguan,Hualin Sun,Songlin Zhou,Xiaoming Yang,Gang Chen,Wenfeng Su,Yun Gu

Annals of translational medicine（2022）

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摘要

Taken together, these findings demonstrated a previously unknown role of Etv1 in SC differentiation and myelination, providing a candidate molecular target for clinical interventions in demyelinating diseases.

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关键词

Etv1/Er81,Schwann cells (SCs),demyelinating diseases,differentiation,myelination and re-myelination

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