Atorvastatin attenuates NS1 (Non-structural protein-1) of dengue type-2 serotype-induced expressions of matrix metalloproteinases in HL-60 cells, differentiated to neutrophils: Implications for the immunopathogenesis of dengue viral disease

•We highlight the role of neutrophils to carry overexpressed matrix metalloproteinases (MMPs) which participate in the development of dengue pathogenesis especially in the case of dengue shock syndrome.•NS1 exposure to neutrophils, significantly upregulate expression profiles of MMP-1, MMP-2, MMP-9 and MMP-14 which may be responsible for vascular permeability and thus development of dengue shock syndrome.•Atorvastatin has significantly reversed the expression profiles of MMP-2 and MMP-14 showing protective effects.•Further, atorvastatin reversed, NS1 induced release of cytokines IL-6 in dose dependent manner.•NS1 induction of neutrophils significantly upregulate the expression profile of VEGFs which may participate the endothelial dysfunctions.•We also highlight the role of NS1 protein of virus which remains in the blood and causes immunopathogenesis.