GIP Affects Hepatic Fat and Brown Adipose Tissue Thermogenesis but Not White Adipose Tissue Transcriptome in Type 1 Diabetes.

Sebastian Møller Nguyen Heimbürger,Bjørn Hoe,Chris Neumann Nielsen,Natasha Chidekel Bergman,Kirsa Skov-Jeppesen,Bolette Hartmann,Jens Juul Holst,Flemming Dela,Julie Overgaard,Joachim Størling,Tina Vilsbøll,Thomas Fremming Dejgaard,Jesper Foged Havelund,Vladimir Gorshkov,Frank Kjeldsen,Nils Joakim Færgeman, Martin Rønn Madsen,Mikkel B Christensen,Filip Krag Knop

The Journal of clinical endocrinology and metabolism（2022）

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摘要

Six days of subcutaneous GIP infusion in men with type 1 diabetes transiently decreased bone resorption and increased NEFA and β-oxidation. Further, hepatic fat content, and supraclavicular skin temperature were increased without affecting WAT transcriptomics, the circulating proteome, lipids, or inflammatory markers.

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关键词

GIP,brown adipose tissue,cardiovascular disease,hepatic steatosis,type 1 diabetes,white adipose tissue

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