Free Radical Scavenging, Antibacterial potentials and Spectroscopic Characterizations of Benzoyl thiourea derivatives and their metal complexes
Journal of Molecular Structure(2022)
摘要
•Microbial resistance is an evolutionary process and can be defined as, unfitness of existence antimicrobial agents against various infections.•Microbial resistance can be encountered by designing a new and effective antimicrobial agent.•Two series of benzoyl thiourea derivatives (TH01-TH05), (TH06-TH10) and their metal complexes were successfully synthesized in good yields (up to 90%) using efficient two-pot synthesis.•Antimicrobial activity results showed that TH-01, TH-08 and TH-09 have promising antibacterial potential against K. pneumoniae (12 mm) and P. aeruginosa (16 mm and 14 mm) respectively.•The DPPH radical scavenging activity of Co-TH05 showed more potential with IC50 value 11.4±0.2 µg/mL than standard ascorbic acid (IC50 10.8±0.5 µg/mL).
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关键词
Benzoyl,Thiourea,Two-pot synthesis,Copper and cobalt,Antibacterial,Antioxidative
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