Free Radical Scavenging, Antibacterial potentials and Spectroscopic Characterizations of Benzoyl thiourea derivatives and their metal complexes

Journal of Molecular Structure(2022)

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摘要
•Microbial resistance is an evolutionary process and can be defined as, unfitness of existence antimicrobial agents against various infections.•Microbial resistance can be encountered by designing a new and effective antimicrobial agent.•Two series of benzoyl thiourea derivatives (TH01-TH05), (TH06-TH10) and their metal complexes were successfully synthesized in good yields (up to 90%) using efficient two-pot synthesis.•Antimicrobial activity results showed that TH-01, TH-08 and TH-09 have promising antibacterial potential against K. pneumoniae (12 mm) and P. aeruginosa (16 mm and 14 mm) respectively.•The DPPH radical scavenging activity of Co-TH05 showed more potential with IC50 value 11.4±0.2 µg/mL than standard ascorbic acid (IC50 10.8±0.5 µg/mL).
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关键词
Benzoyl,Thiourea,Two-pot synthesis,Copper and cobalt,Antibacterial,Antioxidative
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