Dye-sensitized lanthanide containing nanoparticles for luminescence based applications

Due to their exceptional luminescent properties, lanthanide (Ln) complexes represent a unique palette of probes in the spectroscopic toolkit. Their extremely weak brightness due to forbidden Ln electronic transitions can be overcome by indirect dye-sensitization from the antenna effect brought by organic ligands. Despite the improvement brought by the antenna effect, (bio)analytical applications with discrete Ln complexes as luminescent markers still suffers from low sensitivity as they are limited by the complex brightness. Thus, there is a need to develop nano-objects that cumulate the spectroscopic properties of multiple Ln ions. This review firstly gives a brief introduction of the spectral properties of lanthanides both in complexes and in nanoparticles (NPs). Then, the research progress of the design of Ln-doped inorganic NPs with capping antennas, Ln-complex encapsulated NPs and Ln-complex surface functionalized NPs is presented along with a summary of the various photosensitizing ligands and of the spectroscopic properties (excited-state lifetime, brightness, quantum yield). The review also emphasizes the problems and limitations encountered over the years and the solutions provided to address them. Finally, a comparison of the advantages and drawbacks of the three types of NP is provided as well as a conclusion about the remaining challenges both in the design of brighter NPs and in the luminescence based applications.