TBX20 Improves Contractility and Mitochondrial Function During Direct Human Cardiac Reprogramming.

Yawen Tang,Sajesan Aryal, Xiaoxiao Geng,Xinyue Zhou,Vladimir G Fast,Jianyi Zhang,Rui Lu,Yang Zhou

Circulation（2022）

引用 13|浏览20

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摘要

TBX20 consolidates MGT cardiac reprogramming factors to activate cardiac enhancers to promote cardiac cell fate conversion. Human induced cardiomyocytes generated with TBX20 showed enhanced cardiac function in contractility and mitochondrial respiration.

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关键词

cellular reprogramming,fibroblasts,heart,myocytes, cardiac,regeneration,transcription factors

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