Protective role of Nrf2 in zinc oxide nanoparticles-induced lung inflammation in female mice and sexual dimorphism in susceptibility

Radwa Sehsah,Wenting Wu,Sahoko Ichihara,Naozumi Hashimoto,Cai Zong, Kyoka Yamazaki, Harue Sato,Ken Itoh,Masayuki Yamamoto,Ahmed Ali Elsayed,Soheir El-Bestar, Emily Kamel,Gaku Ichihara

Toxicology Letters（2022）

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摘要

•Nrf2 protects female mice against increase in BALF eosinophils.•Female mice are less susceptible to lung tissue inflammation than male mice.•Nrf2 and ZnO-NP synergistically regulate expression of GcLc, GR, HO-1, TGF-β or TNFα.

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关键词

Nrf2,ZnO-NPs,BALF,KC,MIP-2,IL,MCP-1,SOD1,NQO1,GcLc,GR,TGF-β,HO-1,TNF-α

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