Region-specific genomic signatures of multidrug-resistant Helicobacter pylori isolated from East and South India

Shakti Kumar,Tanshi Mehrotra,Daizee Talukdar,Jyoti Verma,Bipul Chandra Karmakar,Sangita Paul,Sujit Chaudhuri,Agila Kumari Pragasam,Susmita Bakshi,Shashi Kumari,Meenal Chawla,Ayushi Purohit,Sonali Porey Karmakar,Ankur Mutreja,Sayantan Banerjee,Animesh Ray,Thandavarayan Ramamurthy, Asish K Mukhopadyay,Bhabatosh Das

Gene（2022）

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摘要

•Antimicrobial resistance attributes are increasingly enriching in the genome of Helicobacter pylori.•Genome sequence and resistance traits are very heterogenous in H. pylori.•Comparative analysis of 143 whole-genome sequences of H. pylori identified multiple antibiotic resistance and virulence factors.•Current findings reveal the differential distribution of antibiotic resistance genes in the H. pylori strains.

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关键词

Genome,Multidrug-resistance,H. pylori,Virulence,Mobile genetic element

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