Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes

Mille Kronborg Lyhne,Karina Poulsdóttir Debes, Terese Helgogaard,Andreas Vegge,Jonas Kildegaard,Ulrik Pedersen-Bjergaard,Lisbeth Høier Olsen

Journal of Pharmacological and Toxicological Methods（2022）

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摘要

ECG parameters were influenced by time setting, diurnal variation and lead. Some ECG and HRV changes were found in diabetic minipigs four months after STZ induction. The findings underline the need for standardisation of ECG and HRV in Göttingen Minipigs.

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关键词

Electrocardiography,Diabetes,Porcine,Translational,Methods,Heart rate variability,Arrhythmia,Göttingen Minipigs,Cardiovascular disease

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