Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease

Julia Wollenhaupt,Janina Frisch, Eva Harlacher, Dickson W.L. Wong,Han Jin,Corinna Schulte, Sonja Vondenhoff,Julia Moellmann,Barbara Mara Klinkhammer, Li Zhang, Adelina Baleanu-Curaj,Elisa A. Liehn, Thimoteus Speer,Andrey Kazakov, Christian Werner,Emiel P.C. van der Vorst, Simina-Ramona Selejan,Mathias Hohl, Michael Böhm,Rafael Kramann

Redox Biology（2022）

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摘要

•Development of a CKD mouse model with a clear cardiac functional or morphological phenotype is challenging.•Cardiac oxidative stress response as well as oxidative stress markers are increased in a broad spectrum of CKD mouse models.•Our findings suggest need of additional cardiovascular hits to clearly induce uremic cardiomyopathy as observed in patients.

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关键词

Cardiomyopathy,Chronic kidney disease,Animal model,Oxidative stress,Cardiac remodeling

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