Polygenic Risk Scores for Prediction of Subclinical Coronary Artery Disease in Persons With Human Immunodeficiency Virus (HIV): The Swiss HIV Cohort Study.

Isabella C Schoepf,Christian W Thorball,Helen Kovari,Bruno Ledergerber,Ronny R Buechel,Alexandra Calmy,Rainer Weber,Philipp A Kaufmann,René Nkoulou, Johannes M Schwenke,Dominique L Braun,Jacques Fellay,Philip E Tarr

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2023）

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摘要

In Swiss PWH, subclinical CAD is independently associated with an individual CAD-associated PRS. Combining nongenetic and genetic cardiovascular risk factors provided the most powerful subclinical CAD prediction.

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关键词

HIV infection,aging,multivariable analysis,polygenic risk score,subclinical coronary artery disease

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