Determination and pharmacokinetic study of riociguat by UPLC-MS/MS in human plasma

Omer Faruk Kocak,Mevlut Albayrak,Mehmet Emrah Yaman,Alptug Atila,Yucel Kadioglu,Omer Araz

Journal of Chromatography B（2022）

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摘要

•This method had high sensitivity, high recovery, and a high correlation coefficient.•This method is the first UPLC-MS/MS method for the determination of riociguat from human plasma.•The developed method was used successfully for a pharmacokinetic study of riociguat.

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关键词

Riociguat,UPLC–MS/MS,Method Validation,Pulmonary Hypertension

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