Transcriptomic Response to Calcium in Normal Colon Organoids is Impacted by Colon Location and Sex.

Matthew A M Devall,Christopher H Dampier,Stephen Eaton,Mourad Wagdy Ali,Sarah J Plummer,Jennifer Bryant,W James Gauderman,Ulrike Peters,Steven M Powell,Graham Casey

Cancer prevention research (Philadelphia, Pa.)（2022）

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摘要

A chemopreventive role for calcium in colorectal cancer is still unclear. Here, we identify mechanisms through which calcium supplementation may reduce risk. Calcium supplementation increased differentiation and altered expression of colorectal cancer-related genes in a large study of patient-derived colon organoids. These findings were influenced by colon location and sex.

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关键词

normal colon organoids,transcriptomic response,calcium,colon location

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