Bifunctionalized hydrogels promote angiogenesis and osseointegration at the interface of three-dimensionally printed porous titanium scaffolds

Zhenjia Che,Yifu Sun,Wenbin Luo,Liwei Zhu,Youbin Li,Chenyi Zhu,Tengyue Liu,Lanfeng Huang

Materials & Design（2022）

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摘要

•A scaffold is fabricated as a growth factors release system composed of 3D-printed Ti6Al4V and thermosensitive collagen hydrogel.•The composite scaffold induced osteogenic differentiation and angiogenesis via bone morphogenetic protein 9 and vascular endothelial growth factor release.•The osseointegration between bone and scaffold was improved in bone defect.

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关键词

3D-printed porous titanium scaffold,Growth factor,Bioactive interface,Angiogenesis,Osseointegration

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