Functional and morphometric assessment of small-fibre damage in late-onset hereditary transthyretin amyloidosis with polyneuropathy: the controversial relation between small-fibre-related symptoms and diagnostic test findings.

Eleonora Galosi,Luca Leonardi,Pietro Falco,Giuseppe Di Pietro,Alessandra Fasolino,Nicoletta Esposito,Caterina Leone,Giulia Di Stefano,Maurizio Inghilleri,Marco Luigetti,Antonini Giovanni,Andrea Truini

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis（2023）

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摘要

Our findings indicate that functional test parameters reliably reflect neuropathic pain and autonomic symptoms related to small-fibre damage. These findings might help to identify clinically useful biomarkers to assess patient follow-up.

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COMPASS-31,NPSI,QST,Sudoscan,hereditary transthyretin amyloidosis,neuropathic pain,skin biopsy,small-fibre neuropathy

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