UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair.

Ningda Xu,Yue Liu,Shanshan Nai,Yong Tao,Yuehe Ding,Lemei Jia,Qizhi Geng,Jie Li,Yujing Bai,Gong-Hong Wei,Meng-Qiu Dong, Linyi Luo,Mingwei Zhao,Xingzhi Xu,Xiao-Xin Li,Jing Li,Lvzhen Huang

Investigative ophthalmology & visual science（2022）

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摘要

Hence, we propose that one potential mechanism that UBE3D-V379M contributes to AMD pathogenesis might be via defective DNA damage repair linked with oxidative stress and our results offered a potential direction for the treatment of AMD.

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关键词

age-related macular degeneration (AMD), double-strand break repair (DSBR), KAP1, heterochromatin, methionine oxidation, ubiquitin-protein ligase E3D (UBE3D)

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