A Consideration of Fixed Dosing Versus Body Size‐Based Dosing Strategies for Chimeric Antigen Receptor T‐Cell Therapies

Jimmy Zhijian He, Hechuan Wang,KyoungSoo Lim,Song Ren, Fred Rollins, Markus Vallaster, Ryan Wong,Richard Stebbings,Nathan Standifer, Robert Keefe,Alex Phipps,Megan Gibbs

Clinical Pharmacology in Drug Development(2022)

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关键词
CAR-T cell therapies, cellular kinetics, exposure-response models, fixed and body-weight-based dosing
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